Polymeric Nanocomposite Structures Based on Functionalized Graphene with Tunable Properties for Nervous Tissue Replacement

Electroconductive scaffolds can be a promising approach to repair conductive tissues when natural healing fails. Recently, nerve tissue engineering constructs have been widely investigated due the challenges in creating structure with optimized physiochemical and mechanical properties close native tissue. The goal of current study was fabricate graphene-containing polycaprolactone/gelatin/polypyrrole (PCL/gelatin/PPy) polycaprolactone/polyglycerol-sebacate/polypyrrole (PCL/PGS/PPy) intrinsic electrical through an electrospinning process. effect graphene on PCL/gelatin/PPy PCL/PGS/PPy were investigated. Results demonstrated that incorporation remarkably modulated physical such conductivity increased from 0.1 3.9 ± 0.3 S m–1 (from 0 3 wt % graphene) toughness found 76 MPa (PCL/gelatin/PPy 143.4 (PCL/PGS/PPy graphene). Also, elastic moduli 0, 1, 2 reported as 210, 300, 340 kPa system 72, 85, 92 for system. A cell viability noncytotoxic nature resultant scaffolds. sum results presented this suggests both PCL/gelatin/PPy/graphene PCL/PGS/PPy/graphene compositions could biomaterials range replacement or regeneration applications.